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DIPG-61. HISTONE DEACETYLASE INHIBITOR PANOBINOSTAT SYNERGIZES WITH DUAL MTOR INHIBITOR TAK228 TO POTENTIATE KILLING OF DIPG CELLS
We have previously identified activity of the brain-penetrating dual TORC1/2 kinase inhibitor TAK228 (MLN0128) in DIPG. Currently, HDAC inhibitor Panobinostat is in clinical trials in patients with DIPG and is also known to synergize with mTOR inhibition in other cancer types. We hypothesized that T...
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| Опубликовано в: : | Neuro Oncol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012969/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.154 |
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