ATRT-38. TAK228 COMBINES WITH NAVITOCLAX TO ENHANCE PLATINUM-INDUCED CYTOTOXICITY IN AT/RT

Survival in atypical teratoid rhabdoid tumors (AT/RT) is plagued by drug resistance to platinum-intensive therapies. We have previously shown the dual mTORC1/2 inhibitor TAK228 (aka MLN0128) extends survival in orthotopic mouse models of AT/RT by enhancing cisplatin-induced apoptosis. TAK228 decreas...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Rubens, Jeffrey, Wang, Sabrina, Sharma, Shreya, Shah, Smit, Warren, Kathy, Eberhart, Charles, Raabe, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Abstracts
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012780/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.035
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky