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ATRT-38. TAK228 COMBINES WITH NAVITOCLAX TO ENHANCE PLATINUM-INDUCED CYTOTOXICITY IN AT/RT
Survival in atypical teratoid rhabdoid tumors (AT/RT) is plagued by drug resistance to platinum-intensive therapies. We have previously shown the dual mTORC1/2 inhibitor TAK228 (aka MLN0128) extends survival in orthotopic mouse models of AT/RT by enhancing cisplatin-induced apoptosis. TAK228 decreas...
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| Izdano u: | Neuro Oncol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012780/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.035 |
| Oznake: |
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