ATRT-38. TAK228 COMBINES WITH NAVITOCLAX TO ENHANCE PLATINUM-INDUCED CYTOTOXICITY IN AT/RT

Survival in atypical teratoid rhabdoid tumors (AT/RT) is plagued by drug resistance to platinum-intensive therapies. We have previously shown the dual mTORC1/2 inhibitor TAK228 (aka MLN0128) extends survival in orthotopic mouse models of AT/RT by enhancing cisplatin-induced apoptosis. TAK228 decreas...

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Publicado en:Neuro Oncol
Main Authors: Rubens, Jeffrey, Wang, Sabrina, Sharma, Shreya, Shah, Smit, Warren, Kathy, Eberhart, Charles, Raabe, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012780/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.035
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