The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is an invasive and treatment-refractory pediatric brain tumor. Primary DIPG tumors harbor a number of mutations including alterations in PTEN, AKTand PI3K and exhibit activation of mammalian Target of Rapamycin Complex 1 and 2 (mTORC1/2). mTORC1/2 regulate pro...

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Bibliografske podrobnosti
izdano v:Cancer Lett
Main Authors: Miyahara, Hiroaki, Yadavilli, Sridevi, Natsumeda, Manabu, Rubens, Jeffrey, Rodgers, Louis, Kambhampati, Madhuri, Taylor, Isabella, Kaur, Harpreet, Asnaghi, Laura, Eberhart, Charles G., Warren, Katherine E., Nazarian, Javad, Raabe, Eric H.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569904/
https://ncbi.nlm.nih.gov/pubmed/28450157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.04.019
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