LGG-51. METABOLIC PROFILING IN PEDIATRIC LOW GRADE GLIOMA IDENTIFIES GLUTATHIONE DEPLETION AFTER MTORC1 INHIBITION AND VALIDATES EVEROLIMUS AND CARBOPLATIN AS A POTENTIAL COMBINATION THERAPY

The mTOR pathway contributes to the tumorigenicity of aggressive pediatric low grade glioma (pLGG) and TORC1 inhibitors have demonstrated efficacy in treating pLGG cell lines. The FDA-approved TORC1 inhibitor, everolimus, is currently in clinical trials for patients with recurrent/refractory pLGG. W...

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發表在:Neuro Oncol
Main Authors: Poore, Brad, Yuan, Ming, Arnold, Antje, Price, Antionette, Alt, Jesse, Rubens, Jeffrey, Slusher, Barbara, Eberhart, Charles, Raabe, Eric
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012914/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.392
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