DIPG-68. ONCOGENIC MECHANISMS OF H3.3 K27M IN A SPONTANEOUS DIPG MOUSE MODEL

Diffuse intrinsic pontine gliomas (DIPG) are deadly childhood brainstem tumors that comprise approximately half of all pediatric high-grade gliomas (HGG). Recurrent, clonal somatic mutations in histone H3 are a molecular hallmark that distinguish genetic mechanisms underlying pediatric and adult HGG...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Larson, Jon, Kasper, Lawryn, Paugh, Barbara, Wu, Gang, Jin, Hongjian, Fan, Yiping, Kwon, Chang-Hyuk, Finkelstein, David, Silveira, Andre, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Xu, Beisi, Russell, Helen, McKinnon, Peter, Ellison, David, Zhang, Jinghui, Baker, Suzanne
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012755/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.161
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