QOL-53. METFORMIN RESULTS IN HIPPOCAMPAL REMODELING AND IMPROVED MEMORY ENCODING IN PAEDIATRIC BRAIN TUMOR SURVIVORS TREATED WITH CRANIAL RADIATION: A PILOT RANDOMIZED CONTROLLED CROSSOVER STUDY

OBJECTIVES: Although curative, cranial radiation results in hippocampal insult and memory impairment in children with brain tumours. Metformin stimulates hippocampal neurogenesis and improves memory performance in mice. We conducted a pilot double-blind randomized controlled cross-over trial to exam...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Ayoub, Ramy, Miller, Freda, Beera, Kiran, de Medeiros, Cynthia, Laughlin, Suzanne, Bouffet, Eric, Mabbott, Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012547/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.634
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