QOL-53. METFORMIN RESULTS IN HIPPOCAMPAL REMODELING AND IMPROVED MEMORY ENCODING IN PAEDIATRIC BRAIN TUMOR SURVIVORS TREATED WITH CRANIAL RADIATION: A PILOT RANDOMIZED CONTROLLED CROSSOVER STUDY

OBJECTIVES: Although curative, cranial radiation results in hippocampal insult and memory impairment in children with brain tumours. Metformin stimulates hippocampal neurogenesis and improves memory performance in mice. We conducted a pilot double-blind randomized controlled cross-over trial to exam...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Ayoub, Ramy, Miller, Freda, Beera, Kiran, de Medeiros, Cynthia, Laughlin, Suzanne, Bouffet, Eric, Mabbott, Donald
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012547/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.634
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki