Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

We asked whether pharmacological stimulation of endogenous neural precursor cells (NPCs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in parallel rodent and human studies of radiation injury. In the rodent cranial radiation model, we found that metformin enhanced...

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Publicat a:Nat Med
Autors principals: Ayoub, Ramy, Ruddy, Rebecca M., Cox, Elizabeth, Oyefiade, Adeoye, Derkach, Daniel, Laughlin, Suzanne, Ades-aron, Benjamin, Shirzadi, Zahra, Fieremans, Els, Macintosh, Bradley J., de Medeiros, Cynthia B., Skocic, Jovanka, Bouffet, Eric, Miller, Freda D., Morshead, Cindi M., Mabbott, Donald J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176964/
https://ncbi.nlm.nih.gov/pubmed/32719487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0985-2
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