Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

We asked whether pharmacological stimulation of endogenous neural precursor cells (NPCs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in parallel rodent and human studies of radiation injury. In the rodent cranial radiation model, we found that metformin enhanced...

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Veröffentlicht in:Nat Med
Hauptverfasser: Ayoub, Ramy, Ruddy, Rebecca M., Cox, Elizabeth, Oyefiade, Adeoye, Derkach, Daniel, Laughlin, Suzanne, Ades-aron, Benjamin, Shirzadi, Zahra, Fieremans, Els, Macintosh, Bradley J., de Medeiros, Cynthia B., Skocic, Jovanka, Bouffet, Eric, Miller, Freda D., Morshead, Cindi M., Mabbott, Donald J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176964/
https://ncbi.nlm.nih.gov/pubmed/32719487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0985-2
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