DIPG-13. SENSITIVITY OF DIPG CELLS TO BMI-1 MODULATOR PTC596 IS INDEPENDENT OF EZH2 ACTIVITY

Despite numerous advances in understanding the biology of poor-prognosis pediatric brain tumors, DIPG remains essentially incurable. We recently validated BMI-1 as a therapeutic target in DIPG. BMI-1 is a member of the Polycomb repressive complex 1 and is highly expressed in DIPG patient tumors and...

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Vydáno v:Neuro Oncol
Hlavní autoři: Kumar, Shiva Senthil, Sengupta, Satarupa, Lee, Kyungwoo, Drissi, Rachid
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012134/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.106
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