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DIPG-13. SENSITIVITY OF DIPG CELLS TO BMI-1 MODULATOR PTC596 IS INDEPENDENT OF EZH2 ACTIVITY
Despite numerous advances in understanding the biology of poor-prognosis pediatric brain tumors, DIPG remains essentially incurable. We recently validated BMI-1 as a therapeutic target in DIPG. BMI-1 is a member of the Polycomb repressive complex 1 and is highly expressed in DIPG patient tumors and...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012134/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.106 |
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