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LGG-01. EVALUATION OF COBIMETINIB, A MEK INHIBITOR, IN LOW-GRADE PEDIATRIC BRAIN TUMORS
Cobimetinib is an orally bioavailable small-molecule that specifically binds to and inhibits the catalytic activity of MEK, resulting in inhibition of ERK phosphorylation and activation and decreased tumor cell proliferation. Cobimetinib is used clinically in the treatment of BRAFV600-mutant melanom...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012125/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.345 |
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