Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function. We have previously shown that mice with selective loss of Gch1 in endothelial cells have mild vascular dysfunction, but the consequences of en...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Chuaiphichai, Surawee, Rashbrook, Victoria S., Hale, Ashley B., Trelfa, Lucy, Patel, Jyoti, McNeill, Eileen, Lygate, Craig A., Channon, Keith M., Douglas, Gillian
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott, Williams & Wilkins 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012043/
https://ncbi.nlm.nih.gov/pubmed/29844152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11144
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