Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents

Despite the substantial clinical success of aspirin and clopidogrel in secondary prevention of ischemic stroke, up to 40% of patients remain resistant to the available antiplatelet treatment. Therefore, there is an urgent clinical need to develop novel antiplatelet agents with a novel mechanism of a...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Marcinkowska, Monika, Kotańska, Magdalena, Zagórska, Agnieszka, Śniecikowska, Joanna, Kubacka, Monika, Siwek, Agata, Bucki, Adam, Pawłowski, Maciej, Bednarski, Marek, Sapa, Jacek, Starek, Małgorzata, Dąbrowska, Monika, Kołaczkowski, Marcin
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010133/
https://ncbi.nlm.nih.gov/pubmed/29482394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1437155
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