Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives

In this study, a series of compounds derived from 4-methoxy-1<i>H</i>-isoindole-1,3(2<i>H</i>)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics. A library of 4-methoxy-1<i>H</i>-isoindole-1,3(...

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Main Authors: Anna Czopek, Anna Partyka, Adam Bucki, Maciej Pawłowski, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Paulina Koczurkiewicz, Elżbieta Pękala, Anna Jaromin, Bożena Tyliszczak, Anna Wesołowska, Agnieszka Zagórska
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI AG 2020-08-01
Sraith:Molecules
Ábhair:
benzimidazole derivatives
phosphodiesterase 10A
schizophrenia
antipsychotic activity
Rochtain Ar Líne:https://www.mdpi.com/1420-3049/25/17/3868
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