Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives

In this study, a series of compounds derived from 4-methoxy-1H-isoindole-1,3(2H)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics. A library of 4-methoxy-1H-isoindole-1,3(2H)-dione derivatives with various amine moieties was syn...

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Publicat a:Molecules
Autors principals: Czopek, Anna, Partyka, Anna, Bucki, Adam, Pawłowski, Maciej, Kołaczkowski, Marcin, Siwek, Agata, Głuch-Lutwin, Monika, Koczurkiewicz, Paulina, Pękala, Elżbieta, Jaromin, Anna, Tyliszczak, Bożena, Wesołowska, Anna, Zagórska, Agnieszka
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504677/
https://ncbi.nlm.nih.gov/pubmed/32854402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25173868
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