Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HSD1 inhibition at 5 µM and, furthermore, three of them...

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Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: Niinivehmas, Sanna, Postila, Pekka A., Rauhamäki, Sanna, Manivannan, Elangovan, Kortet, Sami, Ahinko, Mira, Huuskonen, Pasi, Nyberg, Niina, Koskimies, Pasi, Lätti, Sakari, Multamäki, Elina, Juvonen, Risto O., Raunio, Hannu, Pasanen, Markku, Huuskonen, Juhani, Pentikäinen, Olli T.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010071/
https://ncbi.nlm.nih.gov/pubmed/29620427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1452919
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