Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

The cholinergic hypothesis has long been a “polar star” in drug discovery for Alzheimer’s disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our efforts in the discovery of cholinesterases inhibitors (C...

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Zhu, Jie, Yang, Hongyu, Chen, Yao, Lin, Hongzhi, Li, Qi, Mo, Jun, Bian, Yaoyao, Pei, Yuqiong, Sun, Haopeng
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010002/
https://ncbi.nlm.nih.gov/pubmed/29405075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1430691
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