Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure–activity relationship study and biologi...

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Chen, Yao, Zhu, Jie, Mo, Jun, Yang, Hongyu, Jiang, Xueyang, Lin, Hongzhi, Gu, Kai, Pei, Yuqiong, Wu, Liang, Tan, Renxiang, Hou, Jing, Chen, Jingyi, Lv, Yang, Bian, Yaoyao, Sun, Haopeng
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011792/
https://ncbi.nlm.nih.gov/pubmed/29278947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1412314
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