Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure–activity relationship study and biologi...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Chen, Yao, Zhu, Jie, Mo, Jun, Yang, Hongyu, Jiang, Xueyang, Lin, Hongzhi, Gu, Kai, Pei, Yuqiong, Wu, Liang, Tan, Renxiang, Hou, Jing, Chen, Jingyi, Lv, Yang, Bian, Yaoyao, Sun, Haopeng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011792/
https://ncbi.nlm.nih.gov/pubmed/29278947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1412314
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