Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease

Five novel tacrine-ferulic acid hybrid compounds (8a–e) were synthesized and their structures were identified on the basis of a detailed spectroscopic analysis. The activities of inhibiting acetyl cholinesterase (AChE) and butyryl cholinesterase (BuChE), reducing self-induced β-amyloid (Aβ) aggregat...

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Publicado no:Molecules
Main Authors: Fu, Yingbo, Mu, Yu, Lei, Hui, Wang, Pu, Li, Xin, Leng, Qiao, Han, Li, Qu, Xiaodan, Wang, Zhanyou, Huang, Xueshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273353/
https://ncbi.nlm.nih.gov/pubmed/27727187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21101338
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