N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC(50) of 2.6 µM as a chemical starting point fo...

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Bibliographic Details
Published in:J Enzyme Inhib Med Chem
Main Authors: Sunduru, Naresh, Svensson, Mona, Cipriano, Mariateresa, Marwaha, Sania, Andersson, C. David, Svensson, Richard, Fowler, Christopher J., Elofsson, Mikael
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009913/
https://ncbi.nlm.nih.gov/pubmed/28114819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1265520
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