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Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain
With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...
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| 發表在: | J Enzyme Inhib Med Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009886/ https://ncbi.nlm.nih.gov/pubmed/28097912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1252757 |
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