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Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...

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書目詳細資料
發表在:J Enzyme Inhib Med Chem
Main Authors: Gabriele, Elena, Ricci, Chiara, Meneghetti, Fiorella, Ferri, Nicola, Asai, Akira, Sparatore, Anna
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009886/
https://ncbi.nlm.nih.gov/pubmed/28097912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1252757
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