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Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins
Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity of STAT depends on their Src homology 2 (SH2) domain-mediated binding to sequences containing phosphorylated tyrosine. Thus, antagonizing th...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3745430/ https://ncbi.nlm.nih.gov/pubmed/23977103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071646 |
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