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Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT(1A) ligands

The 5-hydroxytryptamine (5-HT(1A)) receptors represent an attractive target in drug discovery. In particular, 5-HT(1A) agonists and partial agonists are deeply investigated for their potential role in the treatment of anxiety, depression, ischaemic brain disorder and more recently, of pain. On the o...

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Bibliografiske detaljer
Udgivet i:J Enzyme Inhib Med Chem
Main Authors: Guariento, Sara, Franchini, Silvia, Tonelli, Michele, Fossa, Paola, Sorbi, Claudia, Cichero, Elena, Brasili, Livio
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009877/
https://ncbi.nlm.nih.gov/pubmed/28114832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1247057
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