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CoMFA, CoMSIA and Eigenvalue Analysis on Dibenzodioxepinone and Dibenzodioxocinone Derivatives as Cholesteryl Ester Transfer Protein Inhibitors

CoMFA, CoMSIA and eigenvalue analysis (EVA) were performed to study the structural features of 61 diverse dibenzodioxepinone and dibenzodioxocinone analogues to probe cholesteryl ester transfer protein (CETP) inhibitory activity. Three methods yielded statistically significant models upon assessment...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Xiong, Xu-qiong, Zhao, Dong-mei, Bu, Peng-fei, Liu, Yang, Ren, Jin-hong, Wang, Jian, Cheng, Mao-sheng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245342/
https://ncbi.nlm.nih.gov/pubmed/18794787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules13081822
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