Microprocessor depends on hemin to recognize the apical loop of primary microRNA

Microprocessor, which consists of a ribonuclease III DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) maturation by cleaving primary miRNA transcripts (pri-miRNAs). We recently demonstrated that the DGCR8 dimer recognizes the apical elements of pri-miRNAs, including the UGU motif, to accura...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Nguyen, Tuan Anh, Park, Joha, Dang, Thi Lieu, Choi, Yeon-Gil, Kim, V Narry
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009577/
https://ncbi.nlm.nih.gov/pubmed/29750274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky248
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