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The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation

Thrombin is frequently increased in the CNS after injury yet little is known regarding its effects on neural stem cells. Here we show that the subventricular zone (SVZ) of adult mice lacking the high affinity receptor for thrombin, proteinase activated receptor 1 (PAR1), show increased numbers of So...

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Vydáno v:Sci Rep
Hlavní autoři: Choi, Chan-Il, Yoon, Hyesook, Drucker, Kristen L., Langley, Monica R., Kleppe, Laurel, Scarisbrick, Isobel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008392/
https://ncbi.nlm.nih.gov/pubmed/29921916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27613-9
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