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The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation

Thrombin is frequently increased in the CNS after injury yet little is known regarding its effects on neural stem cells. Here we show that the subventricular zone (SVZ) of adult mice lacking the high affinity receptor for thrombin, proteinase activated receptor 1 (PAR1), show increased numbers of So...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Choi, Chan-Il, Yoon, Hyesook, Drucker, Kristen L., Langley, Monica R., Kleppe, Laurel, Scarisbrick, Isobel A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008392/
https://ncbi.nlm.nih.gov/pubmed/29921916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27613-9
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