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Exploiting Polarity and Chirality to Probe the Hsp90 C-terminus
Inhibition of the Hsp90 C-terminus is an attractive therapeutic approach for the treatment of cancer. Novobiocin, the first Hsp90 C-terminal inhibitor identified, contains a synthetically complex noviose sugar that has limited the generation of structure-activity relationships for this region of the...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008240/ https://ncbi.nlm.nih.gov/pubmed/29720349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.028 |
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