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Alternative approaches to Hsp90 modulation for the treatment of cancer
Hsp90 is responsible for the conformational maturation of newly synthesized polypeptides (client proteins) and the re-maturation of denatured proteins via the Hsp90 chaperone cycle. Inhibition of the Hsp90 N-terminus has emerged as a clinically relevant strategy for anticancer chemotherapeutics due...
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| Publicado no: | Future Med Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406230/ https://ncbi.nlm.nih.gov/pubmed/25367392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.14.89 |
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