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To fold or not to fold: modulation and consequences of Hsp90 inhibition

BACKGROUND: The 90-kDa heat-shock proteins (Hsp90) have rapidly evolved into promising therapeutic targets for the treatment of several diseases, including cancer and neurodegenerative diseases. Hsp90 is a molecular chaperone that aids in the conformational maturation of nascent polypeptides, as wel...

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Bibliografski detalji
Glavni autori: Peterson, Laura B, Blagg, Brian SJ
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784693/
https://ncbi.nlm.nih.gov/pubmed/20161407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.09.17
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