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To fold or not to fold: modulation and consequences of Hsp90 inhibition
BACKGROUND: The 90-kDa heat-shock proteins (Hsp90) have rapidly evolved into promising therapeutic targets for the treatment of several diseases, including cancer and neurodegenerative diseases. Hsp90 is a molecular chaperone that aids in the conformational maturation of nascent polypeptides, as wel...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784693/ https://ncbi.nlm.nih.gov/pubmed/20161407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.09.17 |
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