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Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues

A series of triazole-containing novobiocin analogues has been designed, synthesized and their inhibitory activity determined. These compounds contain a triazole ring in lieu of the amide moiety present in the natural product. The anti-proliferative effects of these compounds were evaluated against t...

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Autori principali: Peterson, Laura B., Blagg, Brian S. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924929/
https://ncbi.nlm.nih.gov/pubmed/20570149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.140
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