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Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways to Promote Potent Adaptive Immune Responses

The involvement of innate receptors that recognize pathogen and danger associated molecular patterns is critical to programming an effective adaptive immune response to vaccination. The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) synergizes with the squalene oil-in-water emulsion (SE)...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Seydoux, Emilie, Liang, Hong, Cauwelaert, Natasha Dubois, Archer, Michelle, Rintala, Nicholas D, Kramer, Ryan, Carter, Darrick, Fox, Christopher B, Orr, Mark T
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008227/
https://ncbi.nlm.nih.gov/pubmed/29769270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701604
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