The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for T(H)1 Induction

The Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) promotes strong T(H)1 and balanced IgG1/IgG2 responses to protein vaccine antigens. This enhanced immunity is sufficient to provide protection against many diseases including tuberculosis and leis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cauwelaert, Natasha Dubois, Desbien, Anthony L., Hudson, Thomas E., Pine, Samuel O., Reed, Steven G., Coler, Rhea N., Orr, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701231/
https://ncbi.nlm.nih.gov/pubmed/26731269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146372
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