Divergence in DNA Specificity among Paralogous Transcription Factors Contributes to Their Differential In Vivo Binding

Paralogous transcription factors (TFs) are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions. Differential genomic targeting by paralogous TFs is generally assumed to be due to interactions with protein co-factors or the chroma...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Shen, Ning, Zhao, Jingkang, Schipper, Joshua L., Zhang, Yuning, Bepler, Tristan, Leehr, Dan, Bradley, John, Horton, John, Lapp, Hilmar, Gordan, Raluca
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008103/
https://ncbi.nlm.nih.gov/pubmed/29605182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.02.009
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