Structural basis for antibody-mediated neutralization of Lassa virus

The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral surface and the critical target for antibody-mediated neutralization. Here we present the crystal structure of the trimer...

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Udgivet i:Science
Main Authors: Hastie, Kathryn M., Zandonatti, Michelle A., Kleinfelter, Lara M., Heinrich, Megan L., Rowland, Megan M., Chandran, Kartik, Branco, Luis M., Robinson, James E., Garry, Robert F., Saphire, Erica Ollmann
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007842/
https://ncbi.nlm.nih.gov/pubmed/28572385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam7260
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