Convergent structures illuminate features for germline antibody binding and pan-Lassa virus neutralization

Lassa virus (LASV) causes hemorrhagic fever and is endemic in West Africa. Protective antibody responses primarily target the LASV surface glycoprotein (GPC) and GPC-B competition group antibodies often show potent neutralizing activity in humans. However, which features confer potent and broadly ne...

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Vydáno v:Cell
Hlavní autoři: Hastie, Kathryn M, Cross, Robert W., Harkins, Stephanie S., Zandonatti, Michelle A., Koval, Anatoliy P., Heinrich, Megan L., Rowland, Megan M., Robinson, James E., Geisbert, Thomas W., Garry, Robert F., Branco, Luis M., Saphire, Erica Ollmann
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814208/
https://ncbi.nlm.nih.gov/pubmed/31398326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.07.020
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