Telomere sequence content can be used to determine ALT activity in tumours

The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme telomerase, or the Alternative Lengthening of Telomeres (ALT) pathway. These distinct molecular pathways are incompletely und...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Lee, Michael, Teber, Erdahl T, Holmes, Oliver, Nones, Katia, Patch, Ann-Marie, Dagg, Rebecca A, Lau, Loretta M S, Lee, Joyce H, Napier, Christine E, Arthur, Jonathan W, Grimmond, Sean M, Hayward, Nicholas K, Johansson, Peter A, Mann, Graham J, Scolyer, Richard A, Wilmott, James S, Reddel, Roger R, Pearson, John V, Waddell, Nicola, Pickett, Hilda A
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Computational Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007693/
https://ncbi.nlm.nih.gov/pubmed/29718321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky297
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