The DNA damage response activates HPV16 late gene expression at the level of RNA processing

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal tha...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Nilsson, Kersti, Wu, Chengjun, Kajitani, Naoko, Yu, Haoran, Tsimtsirakis, Efthymios, Gong, Lijing, Winquist, Ellenor B, Glahder, Jacob, Ekblad, Lars, Wennerberg, Johan, Schwartz, Stefan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007495/
https://ncbi.nlm.nih.gov/pubmed/29596642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky227
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