The DNA damage response activates HPV16 late gene expression at the level of RNA processing

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal tha...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Nilsson, Kersti, Wu, Chengjun, Kajitani, Naoko, Yu, Haoran, Tsimtsirakis, Efthymios, Gong, Lijing, Winquist, Ellenor B, Glahder, Jacob, Ekblad, Lars, Wennerberg, Johan, Schwartz, Stefan
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007495/
https://ncbi.nlm.nih.gov/pubmed/29596642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky227
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