WNK1 kinase and its partners Akt, SGK1 and NBC-family Na(+)/HCO3(−) cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling

Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma cancer stem-like cells (GSC) reside in hypoxic and acidic niches favoring cell quiescence and drug resistance. A hig...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Wanyin, Zebaze, Leonel Nguekeu, Dong, Jihu, Chézeau, Laëtitia, Inquimbert, Perrine, Hugel, Sylvain, Niu, Songlin, Bihel, Fréderic, Boutant, Emmanuel, Réal, Eléonore, Villa, Pascal, Junier, Marie-Pierre, Chneiweiss, Hervé, Hibert, Marcel, Haiech, Jacques, Kilhoffer, Marie-Claude, Zeniou, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007472/
https://ncbi.nlm.nih.gov/pubmed/29930759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25509
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