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WNK1 kinase and its partners Akt, SGK1 and NBC-family Na(+)/HCO3(−) cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma cancer stem-like cells (GSC) reside in hypoxic and acidic niches favoring cell quiescence and drug resistance. A hig...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007472/ https://ncbi.nlm.nih.gov/pubmed/29930759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25509 |
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