Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

Cancer stem-like cells reside in hypoxic and slightly acidic tumor niches. Such microenvironments favor more aggressive undifferentiated phenotypes and a slow growing "quiescent state" which preserves them from chemotherapeutic agents that essentially target proliferating cells. Our object...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zeniou, Maria, Fève, Marie, Mameri, Samir, Dong, Jihu, Salomé, Christophe, Chen, Wanyin, El-Habr, Elias A., Bousson, Fanny, Sy, Mohamadou, Obszynski, Julie, Boh, Alexandre, Villa, Pascal, Assad Kahn, Suzana, Didier, Bruno, Bagnard, Dominique, Junier, Marie-Pierre, Chneiweiss, Hervé, Haiech, Jacques, Hibert, Marcel, Kilhoffer, Marie-Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536076/
https://ncbi.nlm.nih.gov/pubmed/26270679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134793
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