The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma. Among the drugs targeting monoamine receptors, we identified prazosin, an α1‐ and α2B‐...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Assad Kahn, Suzana, Costa, Silvia Lima, Gholamin, Sharareh, Nitta, Ryan T, Dubois, Luiz Gustavo, Fève, Marie, Zeniou, Maria, Coelho, Paulo Lucas Cerqueira, El‐Habr, Elias, Cadusseau, Josette, Varlet, Pascale, Mitra, Siddhartha S, Devaux, Bertrand, Kilhoffer, Marie‐Claude, Cheshier, Samuel H, Moura‐Neto, Vivaldo, Haiech, Jacques, Junier, Marie‐Pierre, Chneiweiss, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130115/
https://ncbi.nlm.nih.gov/pubmed/27138566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505421
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