WNK1 activates SGK1 to regulate the epithelial sodium channel

WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine. Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension. WNKs have been linked to ion carriers, but the und...

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Detalhes bibliográficos
Main Authors: Xu, Bing-e, Stippec, Steve, Chu, Po-Yin, Lazrak, Ahmed, Li, Xin-Ji, Lee, Byung-Hoon, English, Jessie M., Ortega, Bernardo, Huang, Chou-Long, Cobb, Melanie H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177404/
https://ncbi.nlm.nih.gov/pubmed/16006511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504422102
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