LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

Alzheimer’s disease (AD) is a neurodegenerative disease caused by accumulation of amyloid beta (Aβ) plaque and neurofibrillary tangle formation. We have shown in vitro, that knock-down and blockade of the 37 kDa/67 kDa Laminin Receptor (LRP/LR) resulted in reduced Aβ induced cytotoxicity and Aβ accu...

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Publicat a:Oncotarget
Autors principals: Ferreira, Eloise, Bignoux, Monique J., Otgaar, Tyrone C., Tagliatti, Nicolas, Jovanovic, Katarina, Letsolo, Boitelo T., Weiss, Stefan F.T.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007457/
https://ncbi.nlm.nih.gov/pubmed/29930750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25473
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