Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

We have synthesized three peptides from the mdm-2 binding domain of human p53, residues 12–26 (PPLSQETFSDLWKLL), residues 12–20, and 17–26. To enable transport of the peptides across the cell membrane and at the same time to maximize the active mdm-2 binding α-helical conformation for these peptides...

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Main Authors: Kanovsky, Mecheal, Raffo, Anthony, Drew, Lisa, Rosal, Ramon, Do, Tamara, Friedman, Fred K., Rubinstein, Pablo, Visser, Jan, Robinson, Richard, Brandt-Rauf, Paul W., Michl, Josef, Fine, Robert L., Pincus, Matthew R.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC60072/
https://ncbi.nlm.nih.gov/pubmed/11606716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211280698
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