Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes

The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that our previously determined 3D structure of the p53 re...

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Bibliografiska uppgifter
Huvudupphovsmän: Sarafraz-Yazdi, Ehsan, Bowne, Wilbur B., Adler, Victor, Sookraj, Kelley A., Wu, Vernon, Shteyler, Vadim, Patel, Hunaiz, Oxbury, William, Brandt-Rauf, Paul, Zenilman, Michael E., Michl, Josef, Pincus, Matthew R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836618/
https://ncbi.nlm.nih.gov/pubmed/20080680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909364107
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